Meta-Analysis Data on Systemic Lupus Erythematosus and Cognitive Impairment Risk

A 2026 meta-analysis by Yanan Wang integrates data from 7 observational studies involving over 7 million participants. The dataset likely contains pooled effect estimates, odds ratios, and subgroup analysis results quantifying the association between systemic lupus erythematosus and cognitive impairment or dementia. The work was published on figshare under a CC-BY-4.0 license.

Use Cases

• Validate the pooled association between SLE and cognitive impairment based on the reported odds ratio of 1.53.
• Compare risk estimates across subgroups such as cohort studies versus case-control studies mentioned in the results.
• Assess heterogeneity in study findings using the reported I² statistic from the meta-analysis methodology.
• Examine demographic differences in risk based on the subgroup analyses for Asian/non-Asian populations and men/women.

Strengths

• Results are based on a large pooled sample of over 7 million participants from 7 studies.
• Methodology includes quality assessment using the Newcastle-Ottawa Scale and AHRQ checklist.
• Analysis provides specific pooled odds ratios with confidence intervals (e.g., OR=1.53, 95% CI: 1.26–1.85).
• Subgroup analyses are reported for study design, geography, and gender, adding depth to the findings.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analytical tasks.
• The dataset is very small (79.5 KB), suggesting it contains summary results rather than raw study-level data.

Provenance

Source

Yanan Wang via figshare.

Collection Method

Systematic review and meta-analysis of observational studies from PubMed, Embase, and Cochrane Library.

Time Range

Studies from database inception to September 2025.

Freshness

Last updated 2026-06-02 05:42:32; freshness should be verified.

Geography

Includes studies on Asian and non-Asian populations.