Literature Review on the Gut-Brain Axis in Alzheimer's Disease

Alzheimer's disease imposes a growing clinical burden, yet no therapies have been proven to alter its progression. This 4.9 MB PDF by Chenyu Liu summarizes human studies from the past five years, focusing on the gut-brain axis and its role in early detection and therapy. The literature suggests gut microbial changes may precede clinical symptoms, offering potential targets for microbiome-based prevention.

Use Cases

• Identifying microbial dysbiosis patterns associated with Alzheimer's disease based on the review of human studies.
• Analyzing the role of microbial metabolites in neuroinflammation and amyloid pathology as described in the literature.
• Developing AI tools for early detection of Alzheimer's disease based on longitudinal, multi-omics approaches discussed in the review.
• Evaluating microbiome-targeted therapeutic opportunities for Alzheimer's disease based on the summarized mechanisms.

Strengths

• The review focuses on human studies published within a defined 5-year timeframe.
• It adopts a microbiome-centered perspective, emphasizing distinct bacterial and metabolite-driven mechanisms.
• The file is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a literature review PDF, not primary structured data for direct analysis.
• Row count and column-level documentation are absent; data semantics must be inferred from the text.
• The description does not specify the number of studies reviewed or the geographic scope of the included research.

Provenance

Source

figshare

Collection Method

Literature review summarizing human studies.

Time Range

Studies from the past 5 years (as of the review's publication).

Freshness

Last updated 2026-06-04 05:33:07