Impact of β-Glucan Yeast Extract on Melanoma Development and Immune Response in Mice

Experimental data from a study evaluating the immunomodulatory effects of β-glucan yeast extract (β-GESc) on B16F10 melanoma in C57BL/6 mice. The dataset includes flow cytometry results for splenic cell populations, histopathological spleen assessments, hematological analyses, and tumor growth and survival metrics. The data was authored by Bruno Miranda dos Santos Oliveira and published on figshare under a CC-BY-4.0 license in April 2026.

Use Cases

• Analyze the relationship between β-glucan treatment and immune cell counts (macrophages, dendritic cells, NK cells) based on flow cytometry data.
• Model the impact of treatment on tumor growth and survival rates over different days post-inoculation.
• Investigate correlations between spleen structural changes (germinal centers, PALS expansion) and treatment outcomes based on histopathological assessments.
• Study cytokine production (IFN-γ, TNF-α) by CD4+ and CD8+ T cells under anti-CD3 stimulation in treated versus untreated groups.

Strengths

• Data is derived from a controlled experimental model (B16F10 melanoma in C57BL/6 mice) with specific treatment protocols.
• Includes multiple measurement modalities: flow cytometry, histopathology, hematology, and survival/tumor growth tracking.
• Results are described with specific biological findings, such as increased spleen size and absolute numbers of specific immune cell types.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• The dataset is stored in a DOCX file (5.8 MB), which may require extraction and formatting for computational use.

Provenance

Source

figshare

Collection Method

Laboratory experiment using C57BL/6 mice treated with β-GESc and evaluated via flow cytometry, histopathology, and hematological analysis.

Time Range

The study period is not specified, but data points are measured at days post-inoculation (d.p.i.).

Freshness

Last updated 2026-04-20 05:22:59; freshness should be verified.

Geography

Laboratory setting; geographic origin is not specified.