100 differentially expressed miRNAs were identified in DMD muscle tissue, with miR-30c-5p being the most downregulated. Yayu Wang published this integrated analysis of bulk, small, and single-cell RNA-seq data on figshare in May 2026. The dataset likely contains results from differential expression, target prediction, and pathway enrichment analyses.
Use Cases
- Validate miRNA-mRNA regulatory axes based on differential expression analysis results.
- Investigate inflammatory pathway enrichment in SOCS3-positive cells based on single-cell RNA-seq findings.
- Model metabolic process alterations in DMD muscle based on pathway enrichment mapping.
- Benchmark SOCS3 expression levels in myocytes based on hub gene identification.
Strengths
- Integrated analysis combines bulk, small, and single-cell RNA-seq data from four distinct studies.
- Results validated in three biological models: mdx mice, C2C12 myoblasts, and primary skeletal muscle cells.
- Dataset is openly available under a CC-BY-4.0 license.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is 1.8 KB, indicating a very limited scope of data.
Provenance
- Source
- figshare
- Collection Method
- Integrated differential expression analysis, target gene prediction, and functional pathway enrichment mapping of RNA-seq data.
- Freshness
- Last updated 2026-05-22 05:35:35; freshness should be verified.