Human IgG Response to DNABII Protein Domains in 77 Patient Sera

74 of 77 patient sera assessed show a skewed IgG-specific immune response towards non-protective domains of DNABII proteins, which stabilize bacterial biofilms. The data was generated by Kathryn Q. Wilbanks using surface plasmon resonance and ELISA assays on samples from children, adults with COPD, and people with cystic fibrosis. The dataset was last updated on 2026-03 18.

Use Cases

• Analyzing the prevalence of non-protective immune responses based on IgG-specific recognition data from 77 sera.
• Training models to predict immune response skewness based on patient cohorts (children, COPD, cystic fibrosis).
• Supporting vaccine candidate development by quantifying recognition of protective vs. non-protective protein domains.
• Investigating the concept of Original Antigenic Sin in the context of bacterial biofilm proteins.

Strengths

• Data is derived from 77 patient sera across four distinct clinical cohorts.
• Findings are quantified, with 96% (74 of 77) of sera showing a specific skewed response.
• Assays used (surface plasmon resonance and ELISA) are standard, reproducible methods in immunology.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The dataset is a 1.3 MB PDF, which may require text extraction for computational use.

Provenance

Source

Kathryn Q. Wilbanks via figshare.

Collection Method

Data generated via surface plasmon resonance and ELISA assays on patient sera.

Time Range

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Freshness

Last updated 2026-03-18 07:39:04; freshness should be verified.

Geography

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