Neutrophil-to-Lymphocyte Ratio and Mortality in 532 AAV Patients

532 patients diagnosed with ANCA-associated vasculitis at Tianjin Medical University General Hospital between June 2012 and June 2024 were studied. This research investigates the association between the neutrophil-to-lymphocyte ratio biomarker and outcomes like all-cause mortality and end-stage renal disease. The analysis identified a nonlinear mortality risk threshold at an NLR of 10.

Use Cases

• Analyze the association between the neutrophil-to-lymphocyte ratio and all-cause mortality using Cox regression on patient data.
• Investigate the nonlinear relationship between NLR and mortality risk, identifying the threshold of 10 via restricted cubic spline analysis.
• Assess the link between NLR and organ involvement features like fever and renal dysfunction using logistic regression.
• Perform subgroup analysis to compare infection-related mortality proportions between high and low NLR patient groups.

Strengths

• Dataset includes 532 patient records from a single hospital cohort.
• Analysis covers a 12-year time range from June 2012 to June 2024.
• Study employs multiple statistical methods: logistic regression, Cox regression, Kaplan-Meier, and ROC analysis.

Limitations

• Data is presented only in a 124.4 KB PDF report; underlying tabular data is unavailable for direct analysis.
• Sample is from a single hospital in China, limiting geographic generalizability.
• The retrospective study design may introduce selection bias.

Provenance

Source

Yunan Li, Tianjin Medical University General Hospital.

Collection Method

Retrospective study of patients first diagnosed with AAV.

Time Range

June 2012 to June 2024.

Freshness

Data collection ended in June 2024; the study was last updated in March 2026.

Geography

Tianjin, China.