BMI1 Biomarker Study for Endometrial Receptivity and Pregnancy Outcomes

117 patient tissue samples were analyzed to assess BMI1 expression in endometrial receptivity. Meili Liu authored this research, published on figshare in April 2026. The study correlates BMI1 levels with clinical pregnancy outcomes in a 50-patient infertile cohort.

Use Cases

• Train a classifier to predict spontaneous abortion (SA) status using BMI1 expression levels from IHC, qPCR, and western blot measurements.
• Analyze correlations between BMI1 status (positive/negative) and downstream clinical outcomes like bio-chemical pregnancy, clinical pregnancy, and live birth rates.
• Model the relationship between BMI1 expression and upstream regulators (PR, E6AP) or downstream effectors (GATA6, NANOG) to understand pathway activity.
• Validate BMI1's diagnostic utility for endometrial receptivity using the provided Receiver Operating Characteristic (ROC) analysis framework.

Strengths

• Includes data from 117 patient tissue samples (78 elective abortion, 39 spontaneous abortion).
• Clinical follow-up data from a two-year cohort of 50 infertile patients.
• Biomarker levels validated across three measurement methods: IHC, qPCR, and western blot.

Limitations

• The dataset is a 7.5 KB PDF, containing summarized study results rather than raw, tabular patient-level data.
• Sample size is limited to 117 tissue samples and a 50-patient clinical cohort.
• Geographic and demographic details of the patient population are not provided.

Provenance

Source

figshare, authored by Meili Liu.

Collection Method

Endometrial tissues were obtained from patients and analyzed via immunohistochemistry, quantitative real-time PCR, and western blot.

Time Range

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Freshness

Last updated April 2026.

Geography

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