Meta-Analysis of HIF-1α and Glycemic Parameters in Type 2 Diabetes

36 observational studies with 5,979 participants were included in this systematic review and meta-analysis. The work, authored by Yi Su and uploaded in April 2026, evaluates associations between peripheral blood HIF-1α protein levels and glycemic outcomes in patients with type 2 diabetes.

Use Cases

• Validate associations between HIF-1α levels and fasting plasma glucose (FPG) based on the meta-analysis results
• Correlate HIF-1α expression with glycated hemoglobin (HbA1c) levels for clinical risk assessment
• Assess the relationship between HIF-1α and fasting insulin (FINS) in type 2 diabetes populations
• Model insulin resistance using HIF-1α levels and the homeostatic model assessment (HOMA-IR)
• Perform subgroup analyses on geographic factors influencing the HIF-1α-FPG association

Strengths

• Analysis includes 36 studies, providing a substantial evidence base
• Data was extracted from 8 major databases, including Chinese and English sources
• Study quality was assessed using AHRQ criteria by two independent reviewers

Limitations

• The dataset is a PDF document (160.9 KB), not a structured data table; column-level documentation is absent
• Row count is unknown, which may limit suitability assessment for direct data analysis
• Data may reflect geographic or publication bias inherent to the included observational studies

Provenance

Source

Yi Su via figshare

Collection Method

Systematic review and meta-analysis of observational studies from PubMed, Embase, Cochrane Library, Web of Science, Wanfang, CNKI, VIP, and SinoMed.

Time Range

Literature searched from database inception to July 28, 2025.

Freshness

Last updated 2026-04-10 06:02:07

Geography

Studies included are from unspecified geographic locations; subgroup analysis indicated geographic location modified associations.