Melanoma Cell Transcriptomic and Proteomic Data on IL-15 Signaling and Tumor Progression

Sergio Forcelloni's 2026 study analyzes how transmembrane IL-15 signaling modulates melanoma progression. Transcriptomic data from melanoma patients and proteomic profiles from stimulated cell lines reveal stage-specific responses. Five proteins, including PSAP and MARCKS, were identified as consistently and differentially regulated across primary and metastatic tumor stages.

Use Cases

• Identify stage-specific protein effectors of IL-15 reverse signaling based on proteomic profiling data.
• Correlate IL-15 expression with immune activation and EMT transcriptomic programs mentioned in the description.
• Investigate PSAP as a mediator linking immune infiltration (CD8+ T cells, NK cells) and tumor progression.
• Cross-reference identified protein effectors with published NK cell co-culture and EMT cytokine datasets.

Strengths

• Data is derived from transcriptomic analysis of melanoma patients and proteomic profiling of cell lines.
• Identifies five consistently regulated proteins (PSAP, MARCKS, eEF1A1, DDX39B, RACK1) across tumor stages.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 647.1 KB PDF file, which suggests the underlying data tables may not be directly machine-readable.

Provenance

Source

Sergio Forcelloni via figshare.

Collection Method

Transcriptomic analysis of patient data and proteomic profiling of stimulated melanoma cell lines.

Time Range

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Freshness

Last updated 2026-04-15 04:36:42; freshness should be verified.

Geography

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