Third-Trimester Estradiol and Maternal Thyroid Hormone Data from Rats and Human Astrocytes

200 women at ≥28 gestational weeks were studied, with 100 cases of isolated maternal hypothyroxinemia. Higher estradiol levels were associated with a 2.93 odds ratio for IMH and a -1.74 pmol/L decrease in FT4 per doubling. The dataset, authored by Yajing Xu and last updated in April 2026, includes complementary experimental data from Wistar rats and Human Astrocytes.

Use Cases

• Modeling the association between estradiol levels and isolated maternal hypothyroxinemia based on clinical cohort data.
• Investigating pituitary thyroid hormone metabolism adaptations based on rat model findings.
• Analyzing estradiol's effect on DIO2/OATP1C1 expression and T3/T4 ratios based on human astrocyte cell studies.

Strengths

• Clinical cohort includes 200 women with a balanced case-control design (100 IMH, 100 euthyroid).
• Multimodal evidence integrates human clinical data, rat models, and human astrocyte cell experiments.
• Specific statistical associations are reported, such as an OR of 2.93 per doubling of E2 for IMH.

Limitations

• Row count for the clinical and experimental data is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The proposed pituitary adaptation model is described as exploratory rather than a demonstrated human mechanism.

Provenance

Source

figshare, author Yajing Xu.

Collection Method

Clinical study of pregnant women and complementary experimental studies using Wistar rats and Human Astrocytes.

Freshness

Last updated 2026-04-30 04:17:46; freshness should be verified.