Clinical and Experimental Data on TSLP Role in Aortic Aneurysm

632 abdominal aortic aneurysm patients and 24,036 controls from the UK Biobank provided serum TSLP level measurements. This dataset integrates these clinical findings with data from two murine AAA models, mass cytometry immune profiling, and bulk RNA sequencing. The research was authored by Qi Zheng and published on figshare in April 2026.

Use Cases

• Correlate serum TSLP levels with AAA patient status using the 632 case and 24,036 control cohort.
• Analyze CyTOF mass cytometry data to profile aortic macrophage M1/M2 polarization states.
• Investigate transcriptomic pathways from bulk RNA sequencing, such as cytokine-cytokine receptor interaction.
• Compare AAA severity metrics between genetic Tslpr knockout and wild-type murine models.
• Evaluate the effect of pharmacological TSLP neutralization on disease progression in experimental models.

Strengths

• Includes a large human cohort of 24,668 total individuals from the UK Biobank.
• Integrates multi-level evidence from clinical epidemiology, two murine models, CyTOF, and RNA-seq.
• Data supports a clear mechanistic conclusion linking TSLP to macrophage reprogramming.

Limitations

• Primary data is embedded within a 611 KB PDF, limiting direct computational analysis.
• Sample sizes for specific experimental arms (e.g., murine groups) are not provided.
• The dataset is static and represents a single study's findings, not a continuously updated resource.

Provenance

Source

Research study by Qi Zheng, published on figshare.

Collection Method

Integrated analysis of UK Biobank clinical data, murine AAA models, CyTOF, RNA sequencing, and in vitro assays.

Time Range

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Freshness

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Geography

Human data from UK Biobank (United Kingdom); experimental models location unspecified.