Thyroid Autoimmunity and Cardiometabolic Risk in Women with PCOS

1,300 women with confirmed polycystic ovary syndrome were analyzed in a cross-sectional study to evaluate associations between thyroid autoimmunity and cardiometabolic or androgenic severity. The dataset includes results from age-adjusted Firth logistic regression models assessing primary and secondary endpoints like triglyceride-to-HDL-C ratio and glucose tolerance. The data was authored by Natalia Piórkowska and last updated on 2026-05-01.

Use Cases

• Assessing the relationship between thyroid autoimmunity and cardiometabolic endpoints like TG/HDL-C ratio based on the study's primary outcome.
• Comparing alternative definitions of thyroid autoimmunity (TAI_A, TAI_B, TAI_C) on clinical parameters as described in the methods.
• Evaluating associations between anti-TPO positivity and secondary endpoints such as non-HDL-C levels and OGTT glucose results.
• Conducting sensitivity analyses on clinical data, including restriction to euthyroid participants and trimming of extreme values as performed in the study.

Strengths

• Dataset is based on a pre-specified analysis plan with three a priori definitions for thyroid autoimmunity.
• Includes results from a large cohort of 1,300 women with confirmed PCOS.
• Analysis employed multiple sensitivity checks, including bootstrap-based confidence intervals and false discovery rate correction.

Limitations

• The dataset is small at 60.5 KB, indicating limited scope, likely containing summary results rather than raw patient-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for machine learning tasks.

Provenance

Source

figshare

Collection Method

Cross-sectional clinical study using pre-specified exposure definitions and cardiometabolic endpoints.

Freshness

Last updated 2026-05-01 04:14:19; freshness should be verified.