Titin Modulation and Left Ventricular Remodelling in Chronic Mitral Regurgitation

Data Sheet 1_Titin modulation and left ventricular remodelling in chronic primary mitral regurgitation.docx contains results from a study of 16 patients with mitral valve prolapse and severe mitral regurgitation, compared to 6 controls. The research, authored by Lobke L. Pype and shared on figshare under CC-BY-4.0, investigates titin protein modifications as a mechanism for disproportionate left ventricular remodelling. The dataset was last updated on June 3, 2026.

Use Cases

• Analyze correlations between titin isoform ratios and left ventricular volume indices based on echocardiography and MRI data mentioned in the description
• Investigate the relationship between titin phosphorylation levels and myocardial stiffness in patients with disproportionate remodelling
• Compare protein oxidation and ubiquitination patterns in mitral valve prolapse patients versus control subjects

Strengths

• Includes data from 22 human myocardial biopsy samples (16 patients, 6 controls) with associated pre-operative imaging
• Provides specific, statistically significant protein measurement results (e.g., N2BA/N2B isoform ratio 0.589 ± 0.055 vs. 0.479 ± 0.024, p < 0.001)
• Released under a permissive CC-BY-4.0 license for reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset size is 1.5 MB, indicating a relatively small-scale study

Provenance

Source

Lobke L. Pype via figshare

Collection Method

Myocardial biopsies analyzed by gel electrophoresis and western blotting, with pre-operative transthoracic echocardiography and cardiac magnetic resonance imaging.

Freshness

Last updated 2026-06-03 06:15:02; freshness should be verified