Data Sheet 1_TLR7 polymorphisms are associated with COVID-19 susceptibility and severity.p

A case-control study of 261 individuals, including 166 hospitalized COVID-19 patients, conducted by Edyta Paradowska. It analyzes ten pattern-recognition receptor (PRR) gene polymorphisms and their associations with disease severity and cytokine profiles. The data was last updated on 2026-05-28.

Use Cases

• Identify genetic risk factors for severe COVID-19 based on TLR7 polymorphism associations.
• Analyze correlations between specific SNPs and serum cytokine levels like IP-10, IL-10, and TNF-α.
• Investigate the role of pattern-recognition receptor gene variations in viral infection outcomes.

Strengths

• Includes genotype data for 261 individuals, providing a specific cohort size.
• Analyzes ten specific PRR polymorphisms, including TLR3, TLR7, TLR8, IFIH1, and DDX58 SNPs.
• Associates genetic data with quantified clinical parameters and cytokine concentrations.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 298.9 KB, indicating limited scope.

Provenance

Source

Edyta Paradowska

Collection Method

Genotyping performed via qPCR allelic discrimination and PCR-RFLP; cytokine quantification used MILLIPLEX Magnetic Bead Panels and Luminex xMAP technology.

Freshness

Last updated 2026-05-28 06:20:48; freshness should be verified.