Data Sheet 1_TP53 codon 47 and 72 polymorphisms show no association with HPV in Zimbabwean

A cross-sectional study of 102 women living with HIV in Zimbabwe, aged over 18, with histologically confirmed cervical or vulvar disease. The dataset likely contains results from tumor DNA analysis for 17 HPV genotypes and TP53 variants in codon 72 and 47, with associations assessed via logistic regression. The study was authored by Oppah Kuguyo and last updated in April 2026.

Use Cases

• Investigate associations between specific HPV genotypes and TP53 codon polymorphisms based on the described genetic analysis.
• Analyze the prevalence of HPV16 and other genotypes in cervical versus vulvar tissue based on the reported percentages.
• Study the distribution of histological classifications (CIN1-3, cancer) in a cohort of women living with HIV.
• Replicate or extend the logistic regression analysis for TP53 variants and HPV as described in the methods.

Strengths

• Includes data from 102 participants with histologically confirmed disease, providing a defined clinical cohort.
• Reports specific allele frequencies for TP53 codon 72G (34.1% cervical, 29.2% vulvar) and codon 47 T (2.9% cervical, 4.2% vulvar).
• Analyzes 17 HPV genotypes using a multiplex system, offering a multi-genotype perspective.
• Provides clear histological breakdowns (e.g., CIN3: 82%, VIN3: 84.6%).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (37.3 KB), indicating limited scope, likely containing summary results rather than raw individual-level data.

Provenance

Source

figshare

Collection Method

Tumor DNA extracted from formalin-fixed paraffin-embedded tissue biopsies, analyzed for HPV genotypes and TP53 variants via Sanger sequencing.

Time Range

null

Freshness

Last updated 2026-04-20 05:22:17; freshness should be verified.

Geography

Zimbabwe