Transcriptomic Analysis of Immune Dysregulation in ICU Patients with Severe ARDS

Haili Hu's study provides bulk and single-cell transcriptomic data from ICU patients with acute respiratory distress syndrome (ARDS). The dataset, last updated on 2026-05-11, includes analyses identifying immune-related pathways and candidate hub genes H2BC4 and H2BC12. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Identifying differentially expressed genes based on transcriptomic analysis of ARDS patients.
• Validating candidate hub genes like H2BC4 and H2BC12 using in vitro experimental data.
• Analyzing immune cell subset alterations through cell deconvolution methods mentioned in the description.
• Exploring immune-related pathways implicated in ARDS pathogenesis.

Strengths

• Dataset is derived from merged bulk transcriptomic datasets and validated with single-cell transcriptomic data.
• Analysis includes differential expression, WGCNA, and machine learning approaches.
• In vitro experiments with LPS-induced THP-1 cells provide functional validation.

Limitations

• The dataset is small at 128.4 KB, suggesting limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Haili Hu via figshare.

Collection Method

Bulk transcriptomic datasets were merged and analyzed using differential expression, WGCNA, and machine learning.

Freshness

Last updated 2026-05-11 04:21:35.