Data Sheet 1_Transcriptomic and functional profiling of endothelial dysfunction induced by

Primary human umbilical vein endothelial cells (HUVECs) were exposed to carboxylated polystyrene nanoplastics of 30, 50, and 100 nm sizes. The dataset integrates RNA sequencing results with targeted functional assays, revealing dysregulation in cholesterol homeostasis, DNA repair, inflammatory signaling, and endothelial plasticity. It was authored by Joan Martín-Pérez and last updated in April 2026.

Use Cases

• Modeling transcriptomic responses to nanoplastic exposure based on RNA sequencing data.
• Investigating links between nanoplastic exposure and cholesterol homeostasis pathways.
• Analyzing correlations between transcriptomic signatures and functional endpoints like DNA damage and angiogenesis.
• Studying the endothelial-to-mesenchymal transition process triggered by environmental stressors.

Strengths

• Data integrates transcriptomic sequencing with targeted functional assays for mechanistic validation.
• Exposure conditions include three distinct nanoplastic sizes (30, 50, 100 nm) for comparative analysis.
• Released under a CC-BY-4.0 license, permitting open reuse and modification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is provided in a DOCX file format, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Experimental study exposing primary human umbilical vein endothelial cells (HUVECs) to nanoplastics and performing RNA sequencing and functional assays.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-04-16 22:01:33; freshness should be verified.

Geography

Laboratory study; geographic origin of cells or samples not specified.