Zebrafish Larval Transcriptomic Profiles Under Simulated Microgravity

Transcriptomic data from zebrafish larvae exposed to simulated microgravity for 6 to 24 hours, analyzed by Juan D. Carvajal-Agudelo. The dataset includes results from RT-qPCR and transcriptomic analyses focusing on the RANKL/RANK/OPG pathway and other bone-related genes. It was last updated on 2026-05-04.

Use Cases

• Modeling bone resorption pathways based on RANKL/RANK/OPG gene expression data.
• Analyzing time-series gene expression changes in response to simulated microgravity.
• Investigating the role of stress-adaptive pathways like HSP family genes in skeletal regulation.
• Studying the coordinated modulation of bone formation and resorption genes mentioned in the description.

Strengths

• Data is focused on a specific biological pathway (RANKL/RANK/OPG) and includes multiple time points (6, 12, 18, 24 hours).
• Functional enrichment analyses for pathways like WNT, BMP, HIPPO, and MAPK are described.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is very small (11.9 KB), indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.

Provenance

Source

Juan D. Carvajal-Agudelo via figshare.

Collection Method

Transcriptional analysis via RT-qPCR and transcriptomic profiling of zebrafish larvae exposed to simulated microgravity using a Random Positioning Machine.

Time Range

Exposure time points at 6, 12, 18, and 24 hours.

Freshness

Last updated 2026-05-04 09:59:33; freshness should be verified.