Mouse Brain Transcriptomic Data for High-Altitude Cerebral Injury and Oxygen Therapy

Transcriptomic profiling data from a mouse model of high-altitude cerebral injury, comparing normobaric and hyperbaric oxygen therapy. The dataset was created by Xiaojie Hu and last updated on April 13, 2026. It includes RNA-seq results, oxidative stress markers, and protein validation data from brain tissue analysis.

Use Cases

• Identify differentially expressed genes associated with high-altitude hypoxia based on RNA-seq data mentioned in the description.
• Analyze pathway enrichment in NF-κB, PI3K-AKT, and IL-17 signaling based on KEGG analysis results.
• Model the relationship between oxidative stress markers (SOD, MDA, GSH, NO) and therapeutic outcomes.
• Compare transcriptomic restoration patterns between normobaric and hyperbaric oxygen therapy groups.

Strengths

• Includes multi-modal validation data such as Western blot, immunofluorescence, and ELISA alongside RNA-seq.
• Data is associated with a controlled experimental design with four distinct treatment groups.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 45.0 KB, indicating limited scope, likely summary results rather than raw sequencing data.

Provenance

Source

figshare, author Xiaojie Hu.

Collection Method

Data generated from a controlled laboratory study using a mouse model in a hypobaric hypoxia chamber, with subsequent RNA sequencing and biochemical assays.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04 13 05:49:16; freshness should be verified.

Geography

Geographic origin of the study is not specified.