Data Sheet 1_Transcriptomic rewiring of the JAK–STAT pathway in circulating CD4+CLA+ and C

A 2026 research publication by Martin Pook on figshare details transcriptomic and epigenetic data from circulating CD4+CLA+ and CD4+ naïve T cells. The study includes samples from 11 atopic dermatitis patients, 10 psoriasis patients, and 11 healthy individuals, analyzed via ATAC-seq and mRNA sequencing. The data likely contains gene expression and chromatin accessibility profiles related to immune dysregulation.

Use Cases

• Identify shared and unique gene expression signatures in T cell subsets based on the transcriptomic alterations described.
• Analyze chromatin accessibility changes associated with immune regulation based on the epigenetic profiling mentioned.
• Investigate disease-specific rewiring of the JAK-STAT signaling pathway based on the transcriptomic findings.
• Compare molecular alterations between atopic dermatitis and psoriasis based on the patient cohort data.

Strengths

• Includes data from a defined cohort of 32 individuals (11 AD, 10 Ps, 11 healthy).
• Provides paired transcriptomic (mRNA-seq) and epigenetic (ATAC-seq) data from two distinct T cell populations.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data is embedded within an 8.5 MB PDF, requiring extraction for computational analysis.

Provenance

Source

figshare

Collection Method

Circulating T cells were sorted from patient blood samples, followed by ATAC-seq and mRNA sequencing.

Time Range

Publication date suggests data generation likely occurred prior to 2026.

Freshness

Last updated 2026-04-20 05:23:13; freshness should be verified

Geography

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