Rodent Hippocampal Transcriptomics for Active Place Avoidance Memory Maintenance

Isaac Vingan published a transcriptomic dataset on figshare in May 2026. The data measures gene expression changes in the dorsal hippocampus of four Arc-Cre/flox-eYFP transgenic mice three days after consolidation of an active place avoidance memory. It includes results from spatial transcriptomics and single nuclear RNA sequencing, focusing on synaptic and metabolic gene patterns.

Use Cases

• Identify region-specific gene expression patterns in CA1, CA3, and DG based on spatial transcriptomics data.
• Analyze synaptic plasticity and post-synaptic signaling gene enrichment from single nuclear RNA sequencing.
• Study the downregulation of metabolic activity genes across hippocampal sub-regions.
• Compare transcriptomic profiles between memory-trained animals and eYFP mRNA positive spatial spots/nuclei.
• Investigate the sparseness of memory-associated neuronal ensembles during offline memory maintenance.

Strengths

• Data is derived from a transgenic mouse model (Arc-Cre/flox-eYFP) designed to tag memory-associated neurons.
• Analysis combines two techniques: spatial transcriptomics and single nuclear RNA sequencing.
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The sample size is limited to four mice.

Provenance

Source

Isaac Vingan

Collection Method

Spatial transcriptomics and single nuclear RNA sequencing performed on hippocampal tissue.

Freshness

Last updated 2026-05-18 04:10:47; freshness should be verified.