Hepatocellular Carcinoma Chemosensitivity Data with Transferrin Liposome Strategy

Figshare hosts a 597.9 KB DOCX file containing clinical and experimental data on RDM1's role in hepatocellular carcinoma chemosensitivity. The research by Xiaoni Cai analyzes RDM1 prognostic value, post-transcriptional regulation by 5-azacytidine, and the efficacy of a transferrin-modified liposome co-delivery system for doxorubicin. The dataset includes results from DNA damage repair assays, apoptosis assays, and in vitro and in vivo antitumor efficacy evaluations.

Use Cases

• Analyze the correlation between high RDM1 expression levels and poor survival prognosis in hepatocellular carcinoma patients.
• Model the synergistic effect of 5-azacytidine and doxorubicin (ADM) on p53/Bax apoptosis pathway activation using experimental assay data.
• Evaluate the enhanced cellular uptake and tumor specificity of the transferrin-modified liposome (AA@Tf-Lip) system compared to free drug administration.
• Assess the reduction in cardiotoxicity associated with the targeted co-delivery strategy versus conventional chemotherapy.

Strengths

• The dataset is derived from a structured scientific study involving both clinical data analysis and controlled in vitro and in vivo experiments.
• It provides specific mechanistic insights, such as RDM1's regulation of RAD51-mediated homologous recombination repair.
• The research evaluates a novel therapeutic strategy (AA@Tf-Lip) with comparative metrics on tumor inhibition and toxicity.

Limitations

• The primary data is embedded within a 597.9 KB DOCX document, requiring manual extraction for computational analysis.
• The dataset scope is limited to the specific experimental protocols and models described in the associated research paper.
• Sample sizes for clinical data and experimental groups are not specified, limiting statistical power assessment.

Provenance

Source

Figshare, authored by Xiaoni Cai.

Collection Method

Data generated from clinical analysis, molecular biology assays (DNA damage repair, apoptosis), and pharmacological efficacy tests in cell lines and animal models.

Freshness

Last updated on March 23, 2026.