Data Sheet 1_Translational development and first-in-human compassionate infusion of NK-92

A clinical case report details the translational development and compassionate use of engineered SRCD5CAR-NK-92 cells in a patient with multidrug-resistant fusariosis. The 46.8 KB PDF document, authored by María Velasco-de-Andrés and licensed under CC-BY-4.0, was posted on figshare in May 2026. It describes in vitro and in vivo testing, as well as the safety outcomes from escalating intravenous infusions of the cell therapy.

Use Cases

• Analyzing safety and feasibility of first-in-human CAR-NK cell infusions based on the reported absence of significant adverse effects.
• Studying the in vitro potency of engineered NK cells against multidrug-resistant fungal isolates based on the described killing assays.
• Reviewing translational development pathways for compassionate use therapies based on the documented preclinical-to-clinical workflow.

Strengths

• Document is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• Provides specific details on a first-in-human clinical application of a novel cell therapy for a drug-resistant infection.
• Includes results from both in vitro assays and an in vivo model of fungal infection as described.

Limitations

• Dataset is a single 46.8 KB PDF document, representing a very limited scope of one case report.
• Row count and column-level documentation are absent; data is embedded in narrative text.
• Freshness should be verified as the last update date is in the future (2026-05-08).

Provenance

Source

figshare

Collection Method

Clinical case report and associated experimental data.

Freshness

Last updated 2026-05-08 05:56:52; freshness should be verified.