TREM2 Role in Adipogenesis and Obesity: Experimental Data from Mouse Models

A 756.8 KB PDF document authored by Anja Dobrijevic and last updated on April 23, 2026, under a CC-BY-4.0 license. The document presents research data investigating the role of the TREM2 receptor in adipocyte differentiation and adipose tissue remodeling during diet-induced obesity in mice. It compares outcomes from global and conditional TREM2 deletion models.

Use Cases

• Analyzing the effect of TREM2 on adipocyte differentiation based on cell culture model experiments described.
• Comparing adipose tissue morphology and metabolic health between global and conditional TREM2 knockout mice as detailed in the study.
• Investigating the relationship between PDGFR-α+ adipose stem cells and tissue remodeling during obesity based on the experimental findings.

Strengths

• Data is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• The research employs multiple experimental models (three cell culture models and conditional knockout animals) for validation.

Limitations

• The dataset is a 756.8 KB PDF; the underlying raw numerical or image data is not directly accessible.
• Row and column counts are unknown, limiting suitability assessment for computational analysis.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental research involving mouse models and cell culture.

Time Range

Experimental timeframe not specified in metadata.

Freshness

Last updated 2026-04-23 13:39:56; freshness should be verified.

Geography

Geographic scope of the research institution is unknown.