Tularemia and LVS Vaccination T-Cell Response Data

1.0 MB of data comparing human immune responses from LVS vaccination and tularemia infection. The dataset includes analysis of peripheral blood mononuclear cells for proliferation, cytokine-producing memory T cells, and cytokine secretion. Authored by Helena Lindgren and last updated on 2026-05-19.

Use Cases

• Compare memory T-cell subset profiles based on the described transitional, effector, and TEMRA populations.
• Analyze multifunctional CD4 and CD8 T-cell responses based on intracellular cytokine staining data.
• Model the durability of vaccine-induced versus infection-induced immunity based on described persistence differences.
• Investigate cytokine secretion patterns, including MIP-1β expression, from recall-stimulated immune cells.

Strengths

• Data compares two distinct immune stimuli: LVS vaccination and natural tularemia infection.
• Analysis includes multiple immune readouts: proliferation, intracellular cytokine staining, and cytokine secretion.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Helena Lindgren via figshare

Collection Method

Peripheral blood mononuclear cells from vaccinees and convalescent patients were recall-stimulated and analyzed.

Freshness

Last updated 2026-05-19 04:21:05; freshness should be verified.