Dalian Health Cohort: Plasma Homocysteine and MASLD Incidence

A cohort study of 5,184 adults from the Dalian Health Management Cohort (DHMC) between 2014 and 2023, investigating the relationship between plasma homocysteine levels and new-onset metabolic dysfunction-associated steatotic liver disease (MASLD). The dataset likely contains longitudinal clinical and metabolic measurements, with results showing a U-shaped association. The study was authored by Yangxuan He and published on figshare.

Use Cases

• Analyze the nonlinear association between a biomarker (homocysteine) and disease incidence based on the reported U-shaped relationship.
• Validate Cox proportional hazards models for longitudinal health data based on the described methodology.
• Investigate the inflection point of a risk factor (approx. 10 μmol/L Hcy) for metabolic liver disease based on the restricted cubic spline analysis.
• Conduct subgroup analyses on clinical cohorts based on the demographic and metabolic criteria mentioned in the description.
• Study the risk implications of hyperhomocysteinemia (Hcy >15 μmol/L) for hepatic health based on the reported hazard ratios.

Strengths

• Includes 5,184 participants from a defined cohort (DHMC).
• Median follow-up period of 2.66 years provides longitudinal perspective.
• Multivariable-adjusted hazard ratios (HR=1.18 per SD, HR=1.45 for HHcy) are reported.
• Diagnosis used liver ultrasonography and metabolic criteria, suggesting structured clinical data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (29.8 KB), indicating limited scope or summary-level data.

Provenance

Source

Dalian Health Management Cohort (DHMC)

Collection Method

Cohort study with baseline exclusions, follow-up, and Cox/RCS analyses.

Time Range

2014–2023

Freshness

Last updated 2026-04-29 05:57:07; freshness should be verified.

Geography

Dalian, China (likely)