Data Sheet 1_UHR as a systemic sensor of cumulative heat exposure and subclinical cardiova

A 2026 study by Tao Cheng presents data from a retrospective cross-sectional analysis of 64,088 adults in Sichuan, China. It investigates the dose-response relationship between cumulative heat exposure, measured by a 7-day Cumulative Excess Heat Wave Index (CEHWI), and subclinical cardiovascular injury markers. The analysis identifies the Uric Acid-to-HDL Cholesterol Ratio (UHR) as a key metabolic-inflammatory mediator.

Use Cases

• Modeling dose-response relationships between cumulative heat exposure and subclinical cardiovascular injury based on the Cumulative Excess Heat Wave Index (CEHWI).
• Investigating metabolic-inflammatory mediation pathways in environmental health based on the identified role of the Uric Acid-to-HDL Cholesterol Ratio (UHR).
• Conducting subgroup vulnerability analyses for populations like older adults or hypertensive individuals based on the described 'Double-Hit' hypothesis.

Strengths

• Analysis is based on a large-scale population of 64,088 adults.
• The study quantifies heat exposure using a specific, defined metric (Cumulative Excess Heat Wave Index).
• Employs multivariable generalized linear models and causal mediation analysis on 10 candidate metabolic-inflammatory mediators.

Limitations

• The dataset is described in a PDF document (8.7 KB), suggesting the underlying raw data is not directly provided.
• Column-level documentation and sample data are unavailable, requiring inference from the paper's description.
• Row count for the underlying data is unknown, which may limit suitability assessment for direct ML application.

Provenance

Source

figshare, authored by Tao Cheng.

Collection Method

Large-scale, population-based retrospective cross-sectional study.

Freshness

Last updated 2026-05-07 05:42:45.

Geography

Sichuan, China.