Rat Model Data on Homologous Point Acupuncture for Knee Osteoarthritis

Integrated metabolomics and proteomics data from a study comparing homologous point and conventional acupuncture in a rat model of knee osteoarthritis. The dataset includes behavioral scores, cytokine levels, and histopathological assessments from 40 rats across four groups. Author Wu Liu published the data on figshare under a CC-BY-4.0 license in April 2026.

Use Cases

• Identify metabolic pathway alterations in knee osteoarthritis based on integrated metabolomics and proteomics data.
• Compare inflammatory biomarker levels (IL-6, IL-1β, TNF-α, LDH) between acupuncture treatment groups and controls.
• Analyze correlations between behavioral scores (Lequesne MG) and molecular profiles to understand treatment efficacy.
• Investigate protein expression changes related to glycolysis, NLRP3 inflammasome, autophagy, and apoptosis pathways.

Strengths

• Data is derived from a controlled animal study with four distinct groups of 10 rats each.
• Includes multi-omics data (metabolomics and proteomics) for mechanistic investigation.
• Results are validated using multiple methods: histopathology, ELISA, biochemical kits, and Western blotting.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Data is specific to a rat model, and direct translation to human clinical contexts requires caution.
• The 17.0 MB file size suggests a relatively small dataset.

Provenance

Source

figshare

Collection Method

Experimental data from a rat model study involving intra-articular MIA injection, acupuncture treatment, and subsequent multi-omics analysis.

Freshness

Last updated 2026-04-22 10:03:48; freshness should be verified.