Data Sheet 1: Supporting Data for Apoptosis and Mitophagy Study in Cancer

A 7.2 MB PDF document authored by Xiaowen Huang, last updated on 2026-05-15. The file contains supporting data for a study investigating the role of adaptive mitophagy in resistance to DHODH inhibition in cancer therapy. The research used mt-Keima-based reporters and CRISPR/Cas9 models to explore combination strategies with the inhibitor brequinar.

Use Cases

• Validate findings on mitophagy as a resistance mechanism to DHODH inhibition based on the described experimental models.
• Analyze the relationship between mitochondrial reactive oxygen species (mtROS) and protective mitophagy mentioned in the study.
• Investigate the synergistic effects of combining autophagy inhibitors with brequinar for enhanced anti-tumor activity.
• Study the mechanisms of caspase-dependent apoptosis and lipid peroxidation triggered by the described drug combination.

Strengths

• Data is associated with a specific, peer-reviewed research study described in detail.
• The dataset is openly available under a CC-BY-4.0 license.
• File size is precisely 7.2 MB.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The primary data format is a PDF, which may require extraction for computational analysis.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Xiaowen Huang

Collection Method

Likely contains experimental data from cell biology and in vivo studies as described.

Freshness

Last updated 2026-05-15 14:21:16; freshness should be verified.