Data Sheet 1_Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteo

A 2026 study by Sijie Bian investigates the role of uridine in osteoporosis using an ovariectomized mouse model. The research employs integrative multi-omics analyses and in vitro experiments with RAW264.7 cells and bone marrow-derived macrophages. The findings suggest uridine modulates PI3K/Akt–FoxO signaling to inhibit osteoclast differentiation and bone loss.

Use Cases

• Analyzing metabolic remodeling during osteoclast differentiation based on the multi-omics data mentioned.
• Studying the effects of uridine supplementation on osteoclast development and resorptive function based on the described in vitro assays.
• Evaluating potential therapeutic interventions for osteoporosis based on the in vivo mouse model results.
• Investigating the PI3K/Akt–FoxO signaling pathway's role in bone metabolism based on the mechanistic findings.

Strengths

• Includes multi-omics analyses integrating transcriptional and metabolic data.
• Provides experimental validation using both in vitro cell models and an in vivo ovariectomized mouse model.
• Released under a permissive CC-BY-4.0 license.
• File size is 4.3 MB, indicating a focused and manageable document.

Limitations

• The dataset is a single DOCX file; column-level data and sample data are unavailable for direct analysis.
• Row count is unknown, which may limit suitability assessment for computational tasks.
• The description is detailed but specific data structures and formats must be inferred after download.

Provenance

Source

figshare

Collection Method

Integrative multi-omics analyses and experimental biology methods described in the research.

Time Range

Study published in 2026.

Freshness

Last updated 2026-04-27 04:11:27.

Geography

Laboratory research, likely not geographically specific.