Vitamin D-Related Genetic Variants and Breast Cancer Risk in Jordanian Women

300 patients with breast cancer and 300 healthy controls were genotyped for polymorphisms in CYP2R1, CYP27B1, CYP24A1, and DBP genes. Laith N. Al-Eitan authored this case-control study, which was last updated on 2026-05-28. The results suggest associations between specific genotypes and altered breast cancer risk.

Use Cases

• Assess genetic risk factors for breast cancer based on vitamin D metabolism gene polymorphisms.
• Validate findings from other populations in a Jordanian cohort based on the case-control design.
• Investigate genotype-phenotype associations for CYP2R1 and CYP27B1 variants mentioned in the results.

Strengths

• Includes a balanced case-control cohort of 300 patients and 300 controls.
• Genotyping was performed using PCR-based restriction fragment length polymorphism (RFLP) assays.
• Analysis employed multiple statistical approaches to assess associations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's small size (31.3 KB) indicates a limited scope, likely containing summary or variant data rather than individual-level records.

Provenance

Source

Laith N. Al-Eitan

Collection Method

PCR-based restriction fragment length polymorphism (RFLP) assays for genotyping.

Freshness

Last updated 2026-05-28 04:45:28; freshness should be verified.

Geography

Jordanian women