Weighted Gene Co-Expression Network for Johne's Disease in Bos indicus Cattle

Abhisek Sahu's dataset contains results from a transcriptomic analysis of Bos indicus cattle chronically infected with Johne's disease. The data includes 1,905 differentially expressed protein-coding genes and 3,123 differentially expressed lncRNAs, with network analysis identifying 11 co-expressed modules. The dataset was last updated on June 3, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Identify potential diagnostic biomarkers for Johne's disease based on the 12 identified hub genes (e.g., IL7R, TLR4, IFNG).
• Investigate the role of long non-coding RNAs in bovine immune response based on the 22 lncRNAs co-expressed with hub genes.
• Validate gene co-expression modules associated with clinical traits using the identified turquoise module containing 870 protein-coding genes and 934 lncRNAs.
• Perform functional enrichment analysis on pathways related to immune suppression, inflammation, and tissue remodeling mentioned in the results.

Strengths

• Includes a specific count of 1,905 differentially expressed protein-coding genes and 3,123 differentially expressed lncRNAs.
• Analysis is validated via qPCR, as stated in the methods.
• Dataset is small (64.5 KB), facilitating quick download and initial inspection.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset's scale is limited to the specific cohort of Bos indicus cattle studied.
• Freshness should be verified as the last update date is in the future (2026-06-03).

Provenance

Source

figshare, author Abhisek Sahu

Collection Method

RNA sequencing of PBMC transcriptomes from diseased and healthy female desi cattle, followed by differential expression and weighted gene co-expression network analysis.

Freshness

Last updated 2026-06-03 04:27:14