Experimental Data on Plant Extracts Mitigating Tenofovir-Induced Nephrotoxicity

A dataset from a preclinical study investigating the nephroprotective effects of medicinal plant extracts against tenofovir-induced organ toxicity. The data likely contains results from computational screening, in vitro assays, and a 35-day rat model experiment. It was authored by Chaitanya Sankannavar and shared on figshare under a CC-BY-4.0 license.

Use Cases

• Validate computational screening predictions for xanthine oxidase inhibitors based on plant compound libraries.
• Analyze correlations between in vitro XO inhibitory activity and in vivo nephroprotective outcomes.
• Model dose-response relationships for plant extracts on serum biomarkers like creatinine and BUN.
• Compare the antioxidant potential of different plant part extracts using oxidative stress marker data.

Strengths

• Data is derived from a multi-method study combining computational, in vitro, and in vivo approaches.
• The experimental design includes a 35-day animal model, providing longitudinal toxicity data.
• Results cover multiple serum biomarkers and oxidative stress markers, suggesting a detailed profile.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (46.3 KB), indicating limited scope or summary-level results.

Provenance

Source

figshare

Collection Method

Experimental study involving computational screening, extract preparation, in vitro assays, and a rat model.

Freshness

Last updated 2026-04-21 05:34:53; freshness should be verified.