Data Sheet 1_Xinfeng Capsule Attenuates Ankylosing Spondylitis via m6A Modification

A research document describing a study on the molecular mechanism of Xinfeng Capsule in treating ankylosing spondylitis. The study integrates network pharmacology and RNA-sequencing data, validated by in vitro and in vivo models, to investigate the role of m6A RNA modification in regulating the IL-17/NF-κB pathway. The document was authored by Xiang Ding and last updated on 2026-04 16.

Use Cases

• Analyze the relationship between m6A modification and inflammatory gene expression based on the described RNA-sequencing and MeRIP-qPCR data.
• Study the effects of a Traditional Chinese Medicine formula on specific signaling pathways based on the described IL-17/NF-κB pathway analysis.
• Validate bioinformatics predictions of therapeutic targets using the described in vitro co-culture and in vivo mouse models.
• Investigate the role of the long non-coding RNA LINC01579 in inflammatory regulation based on the described gain- and loss-of-function experiments.

Strengths

• The study employs a multi-method validation approach, including network pharmacology, RNA pull-down assays, and in vivo models.
• The document is licensed under CC-BY-4.0, allowing for open sharing and reuse.
• Specific molecular interactions, such as YTHDC1 binding to LINC01579, are described as being directly validated.

Limitations

• The dataset is a 927.5 KB DOC file, suggesting limited scope and likely containing textual results rather than raw experimental data.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The data may reflect the specific experimental and bioinformatics bias inherent to the single study described.

Provenance

Source

figshare, authored by Xiang Ding.

Collection Method

Data likely generated from integrated network pharmacology, RNA-sequencing, and experimental validation in cell and mouse models.

Time Range

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Freshness

Last updated 2026-04-16 04:20:24; freshness should be verified.

Geography

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