Data Sheet 1: Multi-Omics Analysis of Xinnaoxin Tablets for High-Altitude Cardiac Injury

Zhihui Wang published a research data sheet on figshare in 2026. The document details a systems pharmacology study investigating the mechanisms of Xinnaoxin tablets against high-altitude polycythemia and associated cardiac injury in a hypobaric hypoxia mouse model. It includes data from UPLC-Q-TOF-MS metabolite identification, blood parameter analysis, hemorheology, bone marrow cell assays, cytokine levels, echocardiography, oxidative stress markers, and Western blot analyses of signaling pathways.

Use Cases

• Validate systems pharmacology models based on the described multi-level analysis of signaling pathways.
• Benchmark drug efficacy for high-altitude polycythemia based on reported blood parameters and hemorheology data.
• Study cardioprotective mechanisms under hypoxia based on described echocardiography and oxidative stress indicators.
• Analyze the relationship between bone marrow erythropoiesis and cardiac injury based on CD71+ cell and cytokine data.

Strengths

• Data is associated with a detailed methodological description covering UPLC-Q-TOF-MS, histopathology, and Western blot analyses.
• The study employs a multi-level analysis strategy integrating systems pharmacology with experimental validation.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a single 283.2 KB PDF file; the underlying raw data tables are not provided separately.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description is highly specific to a single pharmacological study, limiting generalizability.

Provenance

Source

figshare, author Zhihui Wang.

Collection Method

Generated from a laboratory study using a hypobaric hypoxia mouse model and multi-omics techniques.

Freshness

Last updated 2026-05-28 04:53:05.