Laron Mouse Liver RNA-seq Data on GH Receptor Gene Therapy Effects

448 genes showed significant expression changes in GH-resistant mice following liver-specific GH receptor gene therapy. This RNA-seq dataset compares liver gene expression across wild-type, GHR-deficient (Laron), treated, and control groups of male and female mice. Joshua K. Tay published the data on figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-05-28.

Use Cases

• Analyzing sex-biased gene expression patterns based on the enrichment for sex-biased genes mentioned in the description
• Studying the effects of GH receptor gene therapy on IGF signaling genes like Igf1 and Igfals
• Investigating proto-oncogene upregulation (e.g., Ascl1, Tmprss4) following constitutive promoter-driven gene expression
• Comparing differential gene expression between genetic knockout (GHR-/-) and therapeutic rescue models

Strengths

• Includes data from four distinct experimental groups (wild-type, knockout, treatment, control) for comparison
• Reports specific fold-changes, such as Igf1 and Igfals induction of ~16-fold compared to control
• Provides clear statistical thresholds (p-adj < 0.05) for identifying significant differential expression

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is derived from a specific mouse model, which may limit direct translation to human biology

Provenance

Source

figshare

Collection Method

RNA sequencing (RNA-seq) performed on mouse livers from controlled laboratory experiments.

Freshness

Last updated 2026-05-28 04:56:31; freshness should be verified