Plasma Exosomal Proteomics for Thyroid Disorders and Papillary Carcinoma

45 differentially expressed proteins were identified from plasma exosomes of patients with papillary thyroid carcinoma (PTC), PTC with Hashimoto’s thyroiditis (PTC-W), Hashimoto’s thyroiditis (HT), and healthy controls. The dataset, authored by Yawei Zhang and last updated in 2026, results from an integrative study combining exosome isolation, label-free quantitative proteomics, and bioinformatics. It highlights SVEP1 and IGKV3-7 as promising biomarkers for PTC progression in HT patients.

Use Cases

• Identify candidate protein biomarkers for papillary thyroid carcinoma based on differential expression analysis.
• Investigate molecular pathways linking Hashimoto’s thyroiditis to cancer progression based on extracellular matrix and immune response annotations.
• Validate proteomic discoveries using parallel reaction monitoring (PRM) targets like SVEP1 and IGKV3-7.
• Explore exosomal protein profiles for non-invasive diagnostic tool development.

Strengths

• 45 differentially expressed proteins provide a focused target list for validation.
• Integrative methodology combines discovery proteomics with targeted validation via PRM.
• Data is openly shared under a CC-BY-4.0 license.

Limitations

• The dataset is small, with plasma samples from only 3 patients per group, limiting statistical power.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Exosome isolation and label-free quantitative proteomics on plasma samples from patient cohorts.

Freshness

Last updated 2026-05-25 04:44:41; freshness should be verified.