Mouse Lung Proteomics and Cytokine Data for Millettia Speciosa Asthma Treatment Study

179 differentially expressed proteins were identified in a mouse model of allergic asthma treated with the herb Millettia speciosa. The dataset includes proteomic and cytokine profiling results, such as levels of IgE, IL-4, IL-5, IL-6, and CCL24, generated by Hangrui Yang and last updated in June 2026. It provides molecular evidence for the herb's suppression of eosinophilic inflammation through the CCL24-eosinophil axis.

Use Cases

• Identify protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Analyze the suppression of Th2-mediated inflammation based on cytokine profiles (IgE, IL-4, IL-5, IL-6).
• Investigate immunometabolic reprogramming in asthma based on pathways like complement, lipid transport, and PPAR signaling.
• Study the role of specific hub proteins (Alb, Apoe, Apoa1, Proc, Serpina7) in immune regulation and lipid metabolism.

Strengths

• Proteomic analysis identified 179 differentially expressed proteins with specific functional annotations.
• Cytokine profiling includes quantitative measurements for key markers like IgE, IL-4, IL-5, IL-6, and CCL24.
• Data is associated with a specific, described experimental method (high-resolution DIA proteomics in an OVA-induced mouse model).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 6.7 KB, indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

Hangrui Yang via figshare.

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics and cytokine profiling from an ovalbumin-induced mouse model of allergic asthma.

Freshness

Last updated 2026-06-03 07:42:25; freshness should be verified.