Data Sheet 10: Multi-Omics Analysis of Xinnaoxin Tablets for High-Altitude Cardiac Injury

A research data sheet from a 2026 study by Zhihui Wang, published on figshare under CC-BY-4.0. The 53.8 KB PDF details experimental results on the therapeutic effects of Xinnaoxin tablets on high-altitude polycythemia and associated cardiac injury in a mouse model. It includes multi-level analyses of blood parameters, hemorheology, bone marrow cells, serum cytokines, cardiac histopathology, echocardiography, oxidative stress markers, and Western blot signaling pathway data.

Use Cases

• Analyzing the effects of a traditional medicine on blood cell counts and viscosity based on complete blood parameter and hemorheology data.
• Studying bone marrow erythropoiesis regulation based on the proportion and apoptosis of CD71+ cells mentioned in the description.
• Investigating cardiac injury and protection mechanisms based on histopathology, echocardiography, and oxidative stress indicators (MDA, T-AOC, CAT, SOD).
• Modeling multi-pathway drug action based on Western blot analyses of NF-κB, MAPK, and PI3K/AKT signaling pathways and apoptosis-related proteins (Bax, Bcl-2).

Strengths

• Includes a multi-level analysis combining blood parameters, cellular assays, histopathology, and molecular signaling data.
• The study employs a simulated high-altitude hypoxic environment mouse model, as described in the methods.
• Data is associated with a detailed methodological description including UPLC-Q-TOF-MS for chemical profiling.

Limitations

• The dataset is a 53.8 KB PDF, suggesting it is a summary data sheet rather than a raw, machine-readable data repository.
• Row count and column-level documentation are absent; field semantics must be inferred from the PDF.
• Data may reflect bias inherent to the specific animal model and experimental conditions used.

Provenance

Source

figshare, author Zhihui Wang.

Collection Method

Data generated from laboratory experiments on a hypobaric hypoxia mouse model, using techniques including UPLC-Q-TOF-MS, flow cytometry, echocardiography, and Western blot.

Freshness

Last updated 2026-05-28 04:53:00; freshness should be verified.