Plasma Exosomal Proteomics for Thyroid Disorders, Including Papillary Carcinoma

A proteomics study analyzing plasma-derived exosomes from patients with thyroid disorders. The dataset includes samples from three patients each with papillary thyroid carcinoma (PTC), PTC with Hashimoto's thyroiditis (PTC-W), Hashimoto's thyroiditis (HT), and healthy controls. It was authored by Yawei Zhang and last updated on 2026-05-25.

Use Cases

• Identify candidate protein biomarkers for papillary thyroid carcinoma based on differentially expressed proteins.
• Investigate the molecular link between Hashimoto's thyroiditis and thyroid cancer progression based on pathway enrichment results.
• Validate potential biomarkers like SVEP1 and IGKV3-7 using parallel reaction monitoring (PRM) data.
• Analyze immune response and extracellular matrix interaction pathways implicated in thyroid disorders.

Strengths

• The study identified 45 differentially expressed proteins between key patient groups.
• Validation via parallel reaction monitoring (PRM) confirmed two specific biomarkers, SVEP1 and IGKV3-7.
• Data is openly licensed under CC-BY-4.0.

Limitations

• The dataset is small, with a file size of 168.1 KB, suggesting limited raw data.
• Row and column counts are unknown, which limits suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Exosome isolation and label-free quantitative proteomics applied to patient plasma samples.

Freshness

Last updated 2026-05-25 04:44:42; freshness should be verified.