Mouse Lung Proteome Data for Millettia Speciosa Asthma Treatment Study

A proteomic analysis from a 2026 study investigating the therapeutic effects of Niudali (Millettia speciosa) in an ovalbumin-induced mouse model of allergic asthma. The dataset includes results from high-resolution data-independent acquisition (DIA) lung proteomics and cytokine profiling, identifying 179 differentially expressed proteins. It was authored by Hangrui Yang and shared under a CC-BY-4.0 license.

Use Cases

• Identify protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24-eosinophil axis in allergic inflammation based on the described suppression of CCL24.
• Analyze immunometabolic pathway modulation based on described changes in complement, lipid transport, and PPAR signaling.
• Validate hub protein networks in lung tissue based on identified proteins like Alb, Apoe, Apoa1, Proc, and Serpina7.

Strengths

• Identifies 179 differentially expressed proteins, providing a quantitative molecular profile.
• Integrates proteomic findings with cytokine profiling data (IgE, IL-4, IL-5, IL-6) for validation.
• Uses a high-resolution data-independent acquisition (DIA) proteomics method.

Limitations

• The dataset is small (160.8 KB), indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is derived from a specific mouse model, which may limit direct translation to human asthma.

Provenance

Source

Hangrui Yang via figshare.

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics and cytokine profiling from an ovalbumin-induced mouse model.

Freshness

Last updated 2026-06-03 07:42:25.