Plasma Exosomal Proteomics Data for Thyroid Disorders and Papillary Thyroid Carcinoma

Yawei Zhang published a proteomics dataset on figshare in 2026. The data comprises plasma exosomal protein profiles from patients with papillary thyroid carcinoma (PTC), PTC with Hashimoto’s thyroiditis (HT), HT alone, and healthy controls. The study identified 45 differentially expressed proteins and validated SVEP1 and IGKV3-7 as potential biomarkers.

Use Cases

• Identify potential protein biomarkers for papillary thyroid carcinoma based on differential expression analysis.
• Investigate the molecular link between Hashimoto’s thyroiditis and thyroid cancer progression using exosomal protein profiles.
• Validate candidate biomarkers like SVEP1 and IGKV3-7 using parallel reaction monitoring (PRM) data.

Strengths

• Includes data from four distinct patient cohorts: PTC, PTC-W, HT, and healthy controls.
• Identified 45 differentially expressed proteins between PTC-W and HT groups.
• Validation phase confirmed two specific biomarkers, SVEP1 and IGKV3-7.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 168.4 KB, indicating a limited scope of data.

Provenance

Source

Yawei Zhang via figshare.

Collection Method

Plasma exosomes were isolated and analyzed using label-free quantitative proteomics.

Freshness

Last updated 2026-05-25 04:44:42; freshness should be verified.