Rat Serum Biomarkers for Aging After Early-Life Stress

A 123.1 KB PDF file published on figshare by Pratik R. Chaudhari in May 2026. It describes serum biomarker data from middle-aged male rats subjected to maternal separation, a model of early-life stress. The data includes measurements of corticosterone, trophic factors, oxidative stress markers, lipid profiles, and advanced glycation end-products.

Use Cases

• Analyzing the relationship between early-life stress and serum corticosterone levels mentioned in the description
• Investigating metabolic dysregulation based on reported triglyceride, cholesterol, and LDL measurements
• Studying oxidative stress and antioxidant activity via markers like Ox-LDL, SOD, and catalase
• Examining the accumulation of advanced glycation end-products (AGEs) and related precursors (MGO, sRAGE) in aging
• Correlating reduced trophic factor signaling (BDNF, IGF1) with physiological aging processes

Strengths

• Data is derived from a controlled experimental model (maternal separation in rats) for studying early-life stress
• Analysis includes multiple biomarker categories: hormonal, trophic, oxidative, metabolic, and glycation products
• Dataset is openly available under a CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (123.1 KB), suggesting it contains summary results rather than raw experimental data

Provenance

Source

figshare

Collection Method

Experimental study using the maternal separation model in rats, with subsequent serum analysis.

Time Range

Study focuses on middle-aged rats; specific collection dates are not provided.

Freshness

Last updated 2026-05-04 04:24:32; freshness should be verified

Geography

Geographic origin of the data is not specified.