Meta-Analysis of DNA Repair Gene Polymorphisms and Leukemia Risk

A 2025 meta-analysis of 54 studies investigating associations between DNA repair gene polymorphisms and leukemia risk. The dataset includes results from gene expression analyses performed across Leukemia DB, GEPIA2, and BloodSpot datasets. The work was authored by Honghui Ye and shared under a CC-BY-4.0 license.

Use Cases

• Identifying leukemia risk-associated polymorphisms based on meta-analysis results for genes like XPD and XRCC1
• Analyzing subtype-specific gene expression patterns of DNA repair genes mentioned in the description
• Developing risk stratification models based on the significant polymorphisms identified

Strengths

• Includes results from a systematic review of 54 studies
• Analyzes multiple specific polymorphisms (e.g., ERCC1 C118T, XPD Lys751Gln) across different genetic models
• Integrates findings from three distinct gene expression datasets (Leukemia DB, GEPIA2, BloodSpot)

Limitations

• The primary data file is a 3.3 MB DOCX document; underlying tabular data structure is unknown
• Row count and column-level documentation are absent, requiring manual inspection after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Comprehensive search of PubMed, Web of Science, Scopus, and Cochrane Library until December 3, 2025, followed by meta-analysis and gene expression analysis.

Time Range

Studies included up to December 2025

Freshness

Last updated 2026-04-23 04:21:48

Geography

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