eoPRED: Placental DNA Methylation Scores for Early-Onset Preeclampsia

493 placental samples with DNA methylation data and histopathologic characterization were used to evaluate the eoPRED score. The score was developed by Hannah J. Illing and is associated with early-onset preeclampsia and maternal vascular malperfusion pathology. The dataset was last updated on June 4, 2026.

Use Cases

• Validate the eoPRED DNA methylation score for identifying early-onset preeclampsia based on placental samples.
• Investigate associations between DNA methylation patterns and maternal vascular malperfusion pathology severity.
• Use the score as a proxy for placental dysfunction in datasets lacking detailed pathology information.

Strengths

• Includes 493 placentas with paired DNA methylation and histopathologic data.
• Shows a statistically significant correlation (R=0.34, p<0.01) between the eoPRED score and MVM pathology grade.
• The eoPRED score was significantly higher in the 7 EOPE cases compared to 402 controls (p<0.001).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 139.8 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Placental samples were characterized by a placental pathologist and analyzed using Infinium EPICv1.0 DNA methylation arrays.

Freshness

Last updated 2026-06-04 22:01:26; freshness should be verified.