TSCP: Anti-Inflammatory and Anti-Bacterial Effects in a Mouse Model of Acute Pharyngitis

Data Sheet 2 contains experimental results from a study on a traditional sore-throat composite phytoextract (TSCP). The dataset, authored by Xinyu Zhang and last updated on 2026-05-22, includes findings from an ammonia-induced acute pharyngitis murine model, network pharmacology analysis, and in vitro antimicrobial assays. It provides quantitative measurements of TSCP's effects on inflammatory pathways and bacterial growth.

Use Cases

• Modeling dose-response relationships for anti-inflammatory effects based on behavioral and histopathological outcomes described in the study.
• Analyzing network pharmacology results based on the 22 identified bioactive components and 174 key therapeutic targets.
• Evaluating in vitro antimicrobial efficacy based on reported MIC and MBC values against S. aureus, MRSA, and E. coli.
• Investigating signaling pathway modulation based on the described PI3K/AKT/NF-κB axis and downstream mediators like iNOS, COX-2, and IL-6.

Strengths

• Provides specific quantitative results, including minimum inhibitory concentration (MIC) values of 32, 64, and 256 μg/mL against three bacterial strains.
• Includes results from multiple experimental methodologies: murine model, network pharmacology identifying 22 components and 174 targets, and molecular validation.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical analysis.
• The dataset is very small at 12.5 KB, indicating limited scope and likely a summary of key results rather than raw experimental data.

Provenance

Source

Xinyu Zhang via figshare

Collection Method

Experimental data from a preclinical study employing a murine model, network pharmacology, and in vitro assays.

Freshness

Last updated 2026-05-22 05:58:10; freshness should be verified.