ADGRD1 in Bladder Cancer: Gene Expression and Clinical Prognosis Analysis

A research document analyzing the role of the ADGRD1 gene in bladder cancer progression and angiogenesis. The study uses GEPIA3 datasets for clinical significance and includes results from in vitro and in vivo functional assays. The document was authored by Chen Li and last updated on 2026-05-28.

Use Cases

• Investigating the association between ADGRD1 expression and clinical stage/prognosis in bladder cancer based on GEPIA3 datasets mentioned in the description.
• Studying the functional role of ADGRD1 in promoting cell proliferation, migration, and invasion based on in vitro assay results.
• Analyzing the pro-angiogenic secretome (VEGF, PDGF, IL-8) and its regulation by ADGRD1 based on the described findings.
• Exploring the PI3K/AKT/mTOR signaling cascade as a mechanistic pathway for ADGRD1 activity based on the described Western blot and pharmacological validation.

Strengths

• The document provides a detailed mechanistic study linking a specific gene (ADGRD1) to bladder cancer progression.
• Findings are supported by multiple experimental methods, including clinical data analysis, in vitro assays, and in vivo xenograft models.
• The document is shared under a permissive CC-BY-4.0 license.

Limitations

• The primary data file is a 304.0 KB DOCX document, which is a small text file and not a structured dataset.
• Column-level documentation and sample data are unavailable, making direct computational analysis impossible without data extraction.
• Row count and dataset structure are unknown, limiting suitability assessment for typical ML tasks.

Provenance

Source

figshare, authored by Chen Li.

Collection Method

The description indicates data was analyzed from GEPIA3 datasets and generated via stable cell line manipulation, functional assays (qPCR, Western blot, etc.), and xenograft models.

Freshness

Last updated 2026-05-28 04:53:05.