Data Sheet 2_Altered early-life gut microbiota in offspring of pregnancies complicated by

23 meconium samples from neonates born to mothers with congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH) were compared to 17 control samples. Yiyang Han authored this study, which found lower alpha diversity and reduced Streptococcus abundance in the PH group. The data, last updated in 2026, provides a microbiome-based basis for investigating adverse maternal-fetal outcomes.

Use Cases

• Compare microbial alpha diversity indices between patient groups based on the reported Shannon and observed features indices.
• Analyze differences in genus-level taxa abundance, such as Streptococcus, between neonates from hypertensive and control pregnancies.
• Investigate predicted functional metabolic pathways, like ubiquinone biosynthesis, that were enriched in the pulmonary hypertension group.

Strengths

• Includes a specific comparison of 23 PH group samples versus 17 control samples.
• Reports concrete statistical findings, such as a significant difference in Streptococcus abundance (0.20% vs. 2.09%, P = 0.0072).
• Uses 16S rRNA sequencing, a standard method for microbial profiling.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 14.4 KB, indicating limited scope.

Provenance

Source

Yiyang Han via figshare

Collection Method

First-pass meconium samples collected from neonates and characterized using 16S rRNA sequencing.

Freshness

Last updated 2026-05-29 06:11:30; freshness should be verified.