Axolotl Immunoglobulin Loci Characterization: Updated Genome Assembly

Stephanie Saint Remy-Hernández published an updated genomic characterization of immunoglobulin loci in the Ambystoma mexicanum (axolotl) on March 17, 2026. The 124.6 KB dataset presents results from an alignment-based annotation and manual curation of a novel 29.1 Gbp genome assembly, refined with RNA-Seq data from multiple tissues. It maps the IGH locus to chromosome 13q and details structural variation in the lambda locus.

Use Cases

• Comparative analysis of immunoglobulin gene loci based on the described IGH and lambda locus structures.
• Studying intraspecies structural variation in adaptive immune receptor loci as highlighted in the conclusion.
• Refining gene models for immunoglobulin genes using RNA-Seq data from spleen, liver, lung, heart, and gill tissues.
• Investigating genome assembly quality impacts on gene annotation, as demonstrated by the comparison between the AmbMex60DD and UKY_AmexF1_1 assemblies.

Strengths

• Data is derived from an improved genome assembly with only 220 unmapped scaffolds.
• Gene models were refined using RNA-Seq datasets from five distinct axolotl tissues.
• Published under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 124.6 KB file size suggests a very limited data scope, likely containing summary results rather than raw sequence data.

Provenance

Source

figshare

Collection Method

Alignment-based annotation and manual curation performed on the UKY_AmexF1_1 genome assembly, with refinement using existing RNA-Seq datasets.

Time Range

Publication date is 2026-03-17; temporal coverage of the underlying genomic data is not specified.

Freshness

Last updated 2026-03-17 13:06:57

Geography

Geographic origin of the Ambystoma mexicanum specimens is not specified.