Immune-Autophagy Gene Expression for Postmenopausal Osteoporosis Diagnosis

Zhanfeng Zhang published this dataset on figshare in 2026. It contains gene expression data used to identify three hub genes (CDK2, DDIT3, MAPK8) linked to immune dysregulation and autophagy in postmenopausal osteoporosis. The data underpins a diagnostic model with a reported AUC of 0.91 and includes analyses of immune cell infiltration, regulatory networks, and drug predictions.

Use Cases

• Building diagnostic models for postmenopausal osteoporosis based on identified hub genes (CDK2, DDIT3, MAPK8).
• Analyzing immune cell infiltration patterns in osteoporosis based on gene expression correlations.
• Identifying potential therapeutic drug targets based on predicted interactions with hub genes.
• Studying regulatory networks involving transcription factors and microRNAs in bone metabolism.
• Validating gene expression findings from an ovariectomized mouse model of osteoporosis.

Strengths

• Includes a validated diagnostic model with a reported AUC of 0.91.
• Identifies three specific hub genes (CDK2, DDIT3, MAPK8) with supporting in vivo mouse model data.
• Integrates multiple analysis layers: differential expression, protein-protein interaction networks, immune infiltration, and single-cell RNA-seq.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (344.2 KB), suggesting limited scope or a subset of processed results.

Provenance

Source

figshare

Collection Method

Gene expression analysis integrating limma, WGCNA, and public autophagy-related gene sets, validated with an ovariectomized mouse model.

Freshness

Last updated 2026-06-01 04:17:35; freshness should be verified.